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Physicians must be able to offer accurate and complete information regarding risks and side effects of hormones to patients. These medications have also been found to be effective in the treatment of hirsutism in women. Venous thrombo-embolism as a complication of cross-sex hormone treatment of male-to-female transsexual subjects: Male-to-female hormone therapy causes the hips to rotate slightly forward because of changes in the tendons. Insufficient evidence exists to definitively guide estrogen therapy in transgender women with risk factors or with a personal history of prior VTE, either on or off estrogen. If estrogen therapy is begun prior to pelvis ossification, which occurs around the age of 25, the pelvic outlet and inlet open slightly. The Journal of Clinical Endocrinology and Metabolism.
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